Mirtazapine decreases the pain feeling in healthy participants.

Détails

ID Serval
serval:BIB_93E3F9BEF96A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mirtazapine decreases the pain feeling in healthy participants.
Périodique
Clinical Journal of Pain
Auteur(s)
Arnold P., Vuadens P., Kuntzer T., Gobelet C., Deriaz O.
ISSN
0749-8047 (Print)
ISSN-L
0749-8047
Statut éditorial
Publié
Date de publication
02/2008
Peer-reviewed
Oui
Volume
24
Numéro
2
Pages
116-119
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
OBJECTIVES: The treatment of neuropathic pain is mainly based on antiepileptics, tricyclic antidepressants, and opiates. These drugs have important side effects disturbing the patient's quality of life. Mirtazapine (MTZ) is a new and well-tolerated tricyclic antidepressants with both monoaminergic and opioid properties that might favorably influence pain. The aim of this study was to assess whether MTZ can reduce the pain induced by a standardized stimulus presented to healthy human participants. The nociceptive flexion reflex (NFR) to an electric stimulus was chosen to determine the pain threshold.
METHODS: The effect of MTZ compared to placebo was assessed on 10 healthy participants in a double-blinded cross-over design. The NFR was measured the day after a single oral dose of drug (30 mg) or placebo.
RESULTS: A significant increase in upper limb (+29%, P=0.006) NFR threshold was observed.
DISCUSSION: MTZ increases the pain tolerance in healthy participants. The potential benefit of this effect on pain should be investigated more thoroughly in chronic neuropathic pain patients. The NFR might serve as an additional tool for the monitoring of these patients.
Mots-clé
Adult, Analgesics/administration & dosage, Analgesics/adverse effects, Antidepressive Agents, Tricyclic/administration & dosage, Antidepressive Agents, Tricyclic/adverse effects, Cross-Over Studies, Double-Blind Method, Drug Administration Schedule, Electric Stimulation/adverse effects, Female, Humans, Leg/innervation, Leg/physiopathology, Male, Mianserin/administration & dosage, Mianserin/adverse effects, Middle Aged, Neuralgia/drug therapy, Neuralgia/physiopathology, Nociceptors/drug effects, Nociceptors/physiology, Pain Measurement/drug effects, Pain Threshold/drug effects, Pain Threshold/physiology, Peripheral Nerves/drug effects, Peripheral Nerves/physiopathology, Peripheral Nervous System Diseases/drug therapy, Peripheral Nervous System Diseases/physiopathology, Placebo Effect, Reaction Time/drug effects, Reaction Time/physiology, Reflex/drug effects, Reflex/physiology, Treatment Outcome
Pubmed
Web of science
Création de la notice
10/02/2008 13:26
Dernière modification de la notice
03/03/2018 19:36
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