Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions.

Détails

ID Serval
serval:BIB_93DFC4969736
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions.
Périodique
Biochemical Society Transactions
Auteur(s)
Abderrahmani A., Plaisance V., Lovis P., Regazzi R.
ISSN
0300-5127
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
34
Numéro
Pt 5
Pages
696-700
Langue
anglais
Notes
Journal Article --- Old month value: Nov
Résumé
The last decade has witnessed spectacular progress in the identification of the protein apparatus required for exocytosis of neurotransmitters, peptide hormones and other bioactive products. In striking contrast, our knowledge of the mechanisms determining the expression of the components of the secretory machinery has remained rudimentary. Since modifications in secretory functions are associated with several physiological processes and contribute to the development of human pathologies, a better knowledge of the control of the expression of the genes involved in exocytosis is urgently needed. Recent studies have led to the identification of transcription factors and other regulatory molecules such as microRNAs that modulate the cellular level of key controllers of the exocytotic process. These findings furnish a new perspective for understanding how secretory functions can adapt to normal physiological conditions and shed light on the mechanisms involved in the development of important human diseases such as diabetes mellitus characterized by defective release of bioactive compounds.
Mots-clé
Animals, Exocytosis, Gene Expression Regulation, MicroRNAs, RNA, Messenger, SNARE Proteins, Transcription Factors, rab GTP-Binding Proteins
Pubmed
Web of science
Création de la notice
24/01/2008 15:29
Dernière modification de la notice
03/03/2018 19:36
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