The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations.

Détails

Ressource 1Télécharger: 29164495.pdf (1064.30 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_93C741229D52
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations.
Périodique
International journal of bipolar disorders
Auteur(s)
Duffy A., Vandeleur C., Heffer N., Preisig M.
ISSN
2194-7511 (Print)
ISSN-L
2194-7511
Statut éditorial
Publié
Date de publication
22/11/2017
Peer-reviewed
Oui
Volume
5
Numéro
1
Pages
37
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Relatively little is known about the onset of bipolar disorder, yet the early illness course is already associated with significant morbidity and mortality. Therefore, characterizing the bipolar illness trajectory is key to risk prediction and early intervention advancement.
In this narrative review, we discuss key findings from prospective longitudinal studies of the high-risk offspring of bipolar parents and related meta-analyses that inform us about the clinical trajectory of emerging bipolar disorder. Challenges such as phenotypic and etiologic heterogeneity and the non-specificity of early symptoms and syndromes are highlighted. Implications of the findings for both research and clinical practice are discussed.
Bipolar disorder in young people at familial risk does not typically onset with a hypomanic or manic episode. Rather the first activated episode is often preceded by years of impairing psychopathological states that vary over development and across emerging bipolar subtype. Taking heterogeneity into account and adopting a more comprehensive approach to diagnosis seems necessary to advance earlier identification and our understanding of the onset of bipolar disorder.

Mots-clé
Antecedents, Bipolar disorder, Early course, High-risk, Illness trajectory, Offspring, Stages
Pubmed
Open Access
Oui
Création de la notice
23/11/2017 19:04
Dernière modification de la notice
08/05/2019 22:11
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