DnaA and ORC: more than DNA replication initiators.

Détails

ID Serval
serval:BIB_93C5760E878D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
DnaA and ORC: more than DNA replication initiators.
Périodique
Trends in Cell Biology
Auteur(s)
Scholefield G., Veening J.W., Murray H.
ISSN
1879-3088 (Electronic)
ISSN-L
0962-8924
Statut éditorial
Publié
Date de publication
2011
Volume
21
Numéro
3
Pages
188-194
Langue
anglais
Résumé
Mutations in DNA replication initiator genes in both prokaryotes and eukaryotes lead to a pleiotropic array of phenotypes, including defects in chromosome segregation, cytokinesis, cell cycle regulation and gene expression. For years, it was not clear whether these diverse effects were indirect consequences of perturbed DNA replication, or whether they indicated that DNA replication initiator proteins had roles beyond their activity in initiating DNA synthesis. Recent work from a range of organisms has demonstrated that DNA replication initiator proteins play direct roles in many cellular processes, often functioning to coordinate the initiation of DNA replication with essential cell-cycle activities. The aim of this review is to highlight these new findings, focusing on the pathways and mechanisms utilized by DNA replication initiator proteins to carry out a diverse array of cellular functions.
Mots-clé
Animals, Bacterial Proteins/metabolism, Cell Cycle, DNA/metabolism, DNA Replication, DNA-Binding Proteins/metabolism, Humans, Origin Recognition Complex/metabolism
Pubmed
Web of science
Création de la notice
11/10/2016 16:29
Dernière modification de la notice
03/03/2018 19:35
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