Granulocyte-macrophage colony-stimulating factor and the immune system

Détails

ID Serval
serval:BIB_93B5F9C4C9F4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Granulocyte-macrophage colony-stimulating factor and the immune system
Périodique
Medical Oncology
Auteur(s)
Tarr  P. E.
ISSN
1357-0560
Statut éditorial
Publié
Date de publication
09/1996
Peer-reviewed
Oui
Volume
13
Numéro
3
Pages
133-40
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Sep
Résumé
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine currently used for the reversal of neutropenia associated with cytotoxic chemotherapy, bone marrow and haemopoietic stem cell transplantation. GM-CSF also modulates the function of differentiated white blood cells. In the context of local inflammatory responses, GM-CSF stimulates macrophages for antimicrobial and antitumor effects. GM-CSF further enhances healing and repair by its actions on fibroblasts and epidermal cells. GM-CSF is the pivotal mediator of the maturation and function of dendritic cells, the most important cell type for the induction of primary T cell immune responses. GM-CSF may enhance antibody dependent cellular cytotoxicity (ADCC) in several cell types, and the generation and cytotoxicity of natural killer (NK) cells. On this basis, GM-CSF may be useful for inducing or augmenting antibody responses to antimicrobial vaccines, to enhance killing of intracellular microorganisms, to accelerate epidermal and mucosal wound healing, and to stimulate protective immunity against tumors.
Mots-clé
Adjuvants, Immunologic Animals Antibody Formation Antibody-Dependent Cell Cytotoxicity/immunology Dendritic Cells/immunology Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology/*physiology Hematopoiesis/drug effects Humans *Immune System Immunotherapy Killer Cells, Natural/immunology Wound Healing/drug effects
Pubmed
Web of science
Création de la notice
20/01/2008 17:55
Dernière modification de la notice
03/03/2018 19:35
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