Study of unipolar electrogram morphology in a computer model of atrial fibrillation

Détails

ID Serval
serval:BIB_938F26F25E03
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Study of unipolar electrogram morphology in a computer model of atrial fibrillation
Périodique
Journal of Cardiovascular Electrophysiology
Auteur(s)
Jacquemet  V., Virag  N., Ihara  Z., Dang  L., Blanc  O., Zozor  S., Vesin  J. M., Kappenberger  L., Henriquez  C.
ISSN
1045-3873 (Print)
Statut éditorial
Publié
Date de publication
10/2003
Volume
14
Numéro
10 Suppl
Pages
S172-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
INTRODUCTION: Electrograms exhibit a wide variety of morphologies during atrial fibrillation (AF). The basis of these time courses, however, is not completely understood. In this study, data from computer models were studied to relate features of the signals to the underlying dynamics and tissue substrate. METHODS AND RESULTS: A computer model of entire human atria with a gross fiber architecture based on histology and membrane kinetics based on the Courtemanche et al. atrial model was developed to simulate paced activation and simulated AF. Unipolar electrograms were computed using a current source approximation at 256 sites in right atrium, to simulate a mapping array. The results show the following: (1) In a homogeneous and isotropic tissue, the presence of highly asymmetric electrograms is rare (<2%), although there is a marked variability in amplitude and symmetry. (2) The introduction of anisotropy increases this variability in symmetry and amplitude of the, electrograms especially for propagation across fibers. The percentage of highly asymmetric electrograms increases to 12% to 15% for anisotropy ratios greater than 3:1. (3) Multiphasic and fractionated electrograms are rarely seen in the model with uniform properties but are more common (15%-17%) in a model including regions with abrupt changes in conductivity. Beat-to-beat variations in the occurrence of multiphasic signals are possible with fixed anatomic heterogeneity, due to beat-to-beat variations in the direction of the wavefront relative to the heterogeneity. CONCLUSION: Analysis of the amplitude and symmetry of unipolar atrial electrograms can provide information about the electrophysiologic substrate maintaining AF.
Mots-clé
Algorithms Anisotropy Atrial Fibrillation/*physiopathology Computer Simulation *Electrocardiography Extracellular Space Heart Conduction System/physiology Humans Magnetic Resonance Imaging Membranes/physiology Models, Biological Myocardium/pathology Myocytes, Cardiac
Pubmed
Web of science
Création de la notice
15/02/2008 12:29
Dernière modification de la notice
03/03/2018 19:35
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