Immunohistochemical expression of P-selectin, SP-A, HSP70, aquaporin 5, and fibronectin in saltwater drowning and freshwater drowning.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_938992852FFF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Immunohistochemical expression of P-selectin, SP-A, HSP70, aquaporin 5, and fibronectin in saltwater drowning and freshwater drowning.
Périodique
International journal of legal medicine
Auteur(s)
Barranco R., Castiglioni C., Ventura F., Fracasso T.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
133
Numéro
5
Pages
1461-1467
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The diagnosis of drowning is one of the most difficult in forensic medicine. The aim of this study was to analyze pulmonary tissue reactions in death by drowning. In particular, we focused on the immunohistochemical expression of P-selectin, SP-A, HSP70, AQP-5, and fibronectin to investigate our expression in drowning and to understand whether there are differences between saltwater drowning (SWD) and freshwater drowning (FWD), which may indicate a different pathophysiology. We retrospectively investigated 10 cases of SWD (Mediterranean Sea) from the Institute of Legal Medicine of Genoa (Italy), and 10 cases of FWD (Lake of Geneva) from the University Center of Legal Medicine of Geneva (Switzerland). As control group, we examined 10 cases of death by acute external bleeding, characterized by minimal respiratory distress. As compared with controls, in SWD cases, the results showed a decrease of SP-A expression with membrane patterns. Furthermore, we observed a greater SP-A expression with granular pattern in drowning cases without statistically significant difference between SWD and FWD. For the markers AQP-5, HSP70, fibronectin, and P-selectin, no statistically significant differences were found between SWD, FWD, and controls.
Mots-clé
Aquaporin 5, Drowning, Fibronectin, Forensic histopathology, Heat shock protein 70, P-selectin, Surfactant protein A
Pubmed
Création de la notice
25/06/2019 8:19
Dernière modification de la notice
04/09/2019 5:10
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