Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.

Favre, G.; Mazzetti, S.; Gengler, C.; Bertelli, C.; Schneider, J.; Laubscher, B.; Capoccia, R.; Pakniyat, F.; Ben Jazia, I.; Eggel-Hort, B.; de Leval, L.; Pomar, L.; Greub, G.; Baud, D.; Giannoni, E.

doi:10.3390/v13122517

Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.

Details

Download: 34960786.pdf (1517.32 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0

Serval ID

serval:BIB_93841AE82729

Type

Article: article from journal or magazin.

Publication sub-type

Case report (case report): feedback on an observation with a short commentary.

Collection

Publications

Institution

UNIL/CHUV

Title

Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.

Journal

Viruses

Author(s)

Favre G., Mazzetti S., Gengler C., Bertelli C., Schneider J., Laubscher B., Capoccia R., Pakniyat F., Ben Jazia I., Eggel-Hort B., de Leval L., Pomar L., Greub G., Baud D., Giannoni E.

ISSN

1999-4915 (Electronic)

ISSN-L

1999-4915

Publication state

Published

Issued date

15/12/2021

Peer-reviewed

Oui

Volume

Number

Pages

2517

Language

english

Notes

Publication types: Case Reports
Publication Status: epublish

Abstract

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.

Keywords

Adult, Brain Injuries/etiology, Brain Injuries/pathology, COVID-19/complications, COVID-19/physiopathology, COVID-19/virology, Cesarean Section, Female, Fetal Movement, Humans, Infant, Newborn, Infant, Premature, Infectious Disease Transmission, Vertical, Leukomalacia, Periventricular/etiology, Leukomalacia, Periventricular/pathology, Placenta/pathology, Placenta/virology, Pregnancy, Pregnancy Complications, Infectious/physiopathology, Pregnancy Complications, Infectious/virology, SARS-CoV-2/isolation & purification, COVID-19, MRI, SARS-CoV-2, brain injury, fetal movements, neurosonography, perinatal, placental

URN

urn:nbn:ch:serval-BIB_93841AE827290

OAI-PMH

oai:serval.unil.ch:BIB_93841AE82729

DOI

10.3390/v13122517

Pubmed

34960786

Web of science

000737193700001

Publisher's website

https://www.mdpi.com/1999-4915/13/12/2517