Obesity-associated changes in molecular biology of primary breast cancer.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_937F9691B6B2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Obesity-associated changes in molecular biology of primary breast cancer.
Journal
Nature communications
Author(s)
Nguyen H.L., Geukens T., Maetens M., Aparicio S., Bassez A., Borg A., Brock J., Broeks A., Caldas C., Cardoso F., De Schepper M., Delorenzi M., Drukker C.A., Glas A.M., Green A.R., Isnaldi E., Eyfjörð J., Khout H., Knappskog S., Krishnamurthy S., Lakhani S.R., Langerod A., Martens JWM, McCart Reed A.E., Murphy L., Naulaerts S., Nik-Zainal S., Nevelsteen I., Neven P., Piccart M., Poncet C., Punie K., Purdie C., Rakha E.A., Richardson A., Rutgers E., Vincent-Salomon A., Simpson P.T., Schmidt M.K., Sotiriou C., Span P.N., Tan KTB, Thompson A., Tommasi S., Van Baelen K., Van de Vijver M., Van Laere S., Van't Veer L., Viale G., Viari A., Vos H., Witteveen A.T., Wildiers H., Floris G., Garg A.D., Smeets A., Lambrechts D., Biganzoli E., Richard F., Desmedt C.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
21/07/2023
Peer-reviewed
Oui
Volume
14
Number
1
Pages
4418
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: epublish
Abstract
Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC differs according to patients' body mass index (BMI) using data from >2,000 patients. We identify several genomic alterations that are differentially prevalent in overweight or obese patients compared to lean patients. We report evidence supporting an ageing accelerating effect of obesity at the genetic level. We show that BMI-associated differences in bulk transcriptomic profile are subtle, while single cell profiling allows detection of more pronounced changes in different cell compartments. These analyses further reveal an elevated and unresolved inflammation of the BC tumor microenvironment associated with obesity, with distinct characteristics contingent on the estrogen receptor status. Collectively, our analyses imply that obesity is associated with an inflammaging-like phenotype. We conclude that patient adiposity may play a significant role in the heterogeneity of BC and should be considered for BC treatment tailoring.
Keywords
Humans, Female, Breast Neoplasms/genetics, Obesity/complications, Obesity/genetics, Molecular Biology, Overweight, Genomics, Tumor Microenvironment
Pubmed
Web of science
Open Access
Yes
Create date
31/07/2023 13:52
Last modification date
23/01/2024 8:30
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