Molecular imaging of matrix metalloproteinases in atherosclerotic plaques.

Détails

ID Serval
serval:BIB_937B4EBFC629
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular imaging of matrix metalloproteinases in atherosclerotic plaques.
Périodique
Thrombosis and Haemostasis
Auteur(s)
Lenglet S., Thomas A., Chaurand P., Galan K., Mach F., Montecucco F.
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Statut éditorial
Publié
Date de publication
2012
Volume
107
Numéro
3
Pages
409-416
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Ischaemic stroke and myocardial infarction often result from the sudden rupture of an atherosclerotic plaque. The subsequent arterial thrombosis occluding the vessel lumen has been widely indicated as the crucial acute event causing peripheral tissue ischaemia. A complex cross-talk between systemic and intraplaque inflammatory mediators has been shown to regulate maturation, remodeling and final rupture of an atherosclerotic plaque. Matrix metalloproteinases (MMPs) are proteolytic enzymes (released by several cell subsets within atherosclerotic plaques), which favour atherogenesis and increase plaque vulnerability. Thus, the assessment of intraplaque levels and activity of MMP might be of pivotal relevance in the evaluation of the risk of rupture. New imaging approaches, focused on the visualisation of inflammation in the vessel wall and plaque, may emerge as tools for individualised risk assessment and prevention of events. In this review, we summarize experimental findings of the currently available invasive and noninvasive imaging techniques, used to detect the presence and activity of MMPs in atherosclerotic plaques.
Mots-clé
Aneurysm, Ruptured/diagnosis, Aneurysm, Ruptured/etiology, Atherosclerosis/complications, Atherosclerosis/diagnosis, Enzyme Activation, Humans, Matrix Metalloproteinases/metabolism, Molecular Imaging, Plaque, Atherosclerotic/enzymology, Risk Assessment
Pubmed
Web of science
Création de la notice
23/02/2015 16:20
Dernière modification de la notice
03/03/2018 19:35
Données d'usage