Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ).

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_933B4E0115CB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ).
Périodique
Neuroimage
Auteur(s)
Draganski B., Ashburner J., Hutton C., Kherif F., Frackowiak R.S., Helms G., Weiskopf N.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
55
Numéro
4
Pages
1423-1434
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Normal ageing is associated with characteristic changes in brain microstructure. Although in vivo neuroimaging captures spatial and temporal patterns of age-related changes of anatomy at the macroscopic scale, our knowledge of the underlying (patho)physiological processes at cellular and molecular levels is still limited. The aim of this study is to explore brain tissue properties in normal ageing using quantitative magnetic resonance imaging (MRI) alongside conventional morphological assessment. Using a whole-brain approach in a cohort of 26 adults, aged 18-85years, we performed voxel-based morphometric (VBM) analysis and voxel-based quantification (VBQ) of diffusion tensor, magnetization transfer (MT), R1, and R2* relaxation parameters. We found age-related reductions in cortical and subcortical grey matter volume paralleled by changes in fractional anisotropy (FA), mean diffusivity (MD), MT and R2*. The latter were regionally specific depending on their differential sensitivity to microscopic tissue properties. VBQ of white matter revealed distinct anatomical patterns of age-related change in microstructure. Widespread and profound reduction in MT contrasted with local FA decreases paralleled by MD increases. R1 reductions and R2* increases were observed to a smaller extent in overlapping occipito-parietal white matter regions. We interpret our findings, based on current biophysical models, as a fingerprint of age-dependent brain atrophy and underlying microstructural changes in myelin, iron deposits and water. The VBQ approach we present allows for systematic unbiased exploration of the interaction between imaging parameters and extends current methods for detection of neurodegenerative processes in the brain. The demonstrated parameter-specific distribution patterns offer insights into age-related brain structure changes in vivo and provide essential baseline data for studying disease against a background of healthy ageing.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/03/2011 11:47
Dernière modification de la notice
08/05/2019 22:09
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