Alveolar macrophages in sarcoidosis coexpress high levels of CD86 (B7.2), CD40, and CD30L.

Détails

ID Serval
serval:BIB_933335536F77
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Alveolar macrophages in sarcoidosis coexpress high levels of CD86 (B7.2), CD40, and CD30L.
Périodique
American Journal of Respiratory Cell and Molecular Biology
Auteur(s)
Nicod L.P., Isler P.
ISSN
1044-1549[print], 1044-1549[linking]
Statut éditorial
Publié
Date de publication
1997
Volume
17
Numéro
1
Pages
91-96
Langue
anglais
Résumé
Alveolar macrophages (AM) from sarcoid patients have been shown to be good antigen presenting cells (APC) unlike normal AM which are usually ineffective. We demonstrate in ten consecutive sarcoid patients that most of their AM, unlike normal AM, do coexpress high levels of CD86, CD40, and CD30L, all known to be important for T-cell activation. CD80 is also slightly more expressed on sarcoid AM than on normal AM, but is detected on only 26 +/- 6% (mean +/- SEM) of sarcoid AM. A good correlation is present between the percentage of sarcoid AM expressing CD86 and CD40 or CD86 and CD30L. However, no correlation is found between the percentage of CD80 and CD86 positive AM in these same patients. Blocking antibodies against CD86 were able to reduce by more than 80% allogeneic T-cell proliferation induced by the AM of sarcoid patients. This study provides evidence that AM can, in pathologic states such as sarcoidosis, express functional costimulatory molecules for T-cell activation such as CD86, thought to be rather specific for more professional APC such as dendritic cells.
Mots-clé
Adult, Aged, Antigens, CD/analysis, Antigens, CD/biosynthesis, Antigens, CD30/immunology, Antigens, CD40/analysis, Antigens, CD40/biosynthesis, Antigens, CD86, Bronchoalveolar Lavage Fluid/immunology, CD30 Ligand, Female, Flow Cytometry, Humans, Immunophenotyping, Lung Neoplasms/immunology, Lymphocyte Activation, Lymphocyte Culture Test, Mixed, Macrophages, Alveolar/immunology, Male, Membrane Glycoproteins/analysis, Membrane Glycoproteins/biosynthesis, Reference Values, Sarcoidosis/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
19/02/2010 19:42
Dernière modification de la notice
03/03/2018 19:34
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