Magnetic Resonance Imaging Correlates of Left Bundle Branch Disease in Patients With Nonischemic Cardiomyopathy.

Détails

ID Serval
serval:BIB_931488D47E03
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Magnetic Resonance Imaging Correlates of Left Bundle Branch Disease in Patients With Nonischemic Cardiomyopathy.
Périodique
The American journal of cardiology
Auteur(s)
Grigoratos C., Liga R., Bennati E., Barison A., Todiere G., Aquaro G.D., Dell'Omodarme M., Emdin M., Masci P.G.
ISSN
1879-1913 (Electronic)
ISSN-L
0002-9149
Statut éditorial
Publié
Date de publication
01/02/2018
Peer-reviewed
Oui
Volume
121
Numéro
3
Pages
370-376
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The pathologic correlates of intraventricular conduction delays in patients with nonischemic cardiomyopathy (NIC) have been scarcely investigated. We assessed left ventricular (LV) structural, functional, and tissue abnormalities associated with intraventricular conduction left bundle disease (LBD), including left anterior hemiblock or complete left bundle branch block, in a cohort of patients with NIC submitted to cardiovascular magnetic resonance. Twelve-lead electrocardiogram and cardiovascular magnetic resonance were performed in 196 consecutive patients with NIC. The presence and extent of myocardial fibrosis was evaluated with late gadolinium enhancement (LGE) technique. Compared with normal intraventricular conduction patients, those with LBD were older (66 vs 59 years, p = 0.001), had greater LV volumes (p = 0.035 for end-diastolic and p = 0.009 for end-systolic volume) and mass (p = 0.034), and showed lower LV ejection fraction (33% vs 40%, p = 0.008). LGE was observed more commonly in LBD than in normal intraventricular conduction patients and was more often located in the ventricular septum (p < 0.001). On multivariate analysis, septal LGE was independently associated with a higher likelihood of LBD (odds ratio 6.1, 95% confidence interval 2.9 to 12.7, p < 0.001), even after correction for LV volumes, mass, and ejection fraction. In conclusion, in NIC, the presence of LBD is associated with worse LV remodeling and dysfunction than normal intraventricular conduction. Septal fibrosis yielded a 6-fold greater likelihood of LBD, independently of the degree of LV dilatation and systolic dysfunction.
Mots-clé
Aged, Bundle-Branch Block/diagnostic imaging, Bundle-Branch Block/physiopathology, Cardiomyopathies/diagnostic imaging, Cardiomyopathies/physiopathology, Contrast Media, Electrocardiography, Female, Humans, Magnetic Resonance Imaging/methods, Male, Middle Aged, Prospective Studies, Ventricular Dysfunction, Left/diagnostic imaging, Ventricular Dysfunction, Left/physiopathology
Pubmed
Web of science
Création de la notice
07/12/2017 22:34
Dernière modification de la notice
20/08/2019 15:55
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