Serum androgen levels in elite female athletes.

Détails

ID Serval
serval:BIB_92F054AAE7CC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Serum androgen levels in elite female athletes.
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Bermon S., Garnier P.Y., Hirschberg A.L., Robinson N., Giraud S., Nicoli R., Baume N., Saugy M., Fénichel P., Bruce S.J., Henry H., Dollé G., Ritzen M.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
99
Numéro
11
Pages
4328-4335
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
OBJECTIVE: Prior to the implementation of the blood steroidal module of the Athlete Biological Passport, we measured the serum androgen levels among a large population of high-level female athletes as well as the prevalence of biochemical hyperandrogenism and some disorders of sex development (DSD).
METHODS AND RESULTS: In 849 elite female athletes, serum T, dehydroepiandrosterone sulphate, androstenedione, SHBG, and gonadotrophins were measured by liquid chromatography-mass spectrometry high resolution or immunoassay. Free T was calculated. The sampling hour, age, and type of athletic event only had a small influence on T concentration, whereas ethnicity had not. Among the 85.5% that did not use oral contraceptives, 168 of 717 athletes were oligo- or amenorrhoic. The oral contraceptive users showed the lowest serum androgen and gonadotrophin and the highest SHBG concentrations. After having removed five doped athletes and five DSD women from our population, median T and free T values were close to those reported in sedentary young women. The 99th percentile for T concentration was calculated at 3.08 nmol/L, which is below the 10 nmol/L threshold used for competition eligibility of hyperandrogenic women with normal androgen sensitivity. Prevalence of hyperandrogenic 46 XY DSD in our athletic population is approximately 7 per 1000, which is 140 times higher than expected in the general population.
CONCLUSION: This is the first study to establish normative serum androgens values in elite female athletes, while taking into account the possible influence of menstrual status, oral contraceptive use, type of athletic event, and ethnicity. These findings should help to develop the blood steroidal module of the Athlete Biological Passport and to refine more evidence-based fair policies and recommendations concerning hyperandrogenism in female athletes.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/08/2014 10:05
Dernière modification de la notice
08/05/2019 22:08
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