Cyclic nucleotide-gated channels. Molecular mechanisms of activation

Détails

ID Serval
serval:BIB_92ED9663AAF7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cyclic nucleotide-gated channels. Molecular mechanisms of activation
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Broillet  M. C., Firestein  S.
ISSN
0077-8923 (Print)
Statut éditorial
Publié
Date de publication
04/1999
Volume
868
Pages
730-40
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Apr 30
Résumé
Activation of cyclic nucleotide-gated (CNG) channels represents the final step in the transduction pathways in both vision and olfaction. Over the past several years, CNG channels have been found in a variety of other cell types where they might fulfill various physiological functions. The olfactory and photoreceptor CNG channels rely on the binding of at least two molecules of cAMP or cGMP at intracellular sites on the channel protein to open a nonspecific cation conductance with a significant permeability to Ca ions. A series of elegant experiments with cloned channels and chimeric constructs has revealed significant information regarding the binding and gating reactions that lead to CNG channel activation. These recent studies have identified several regions as well as specific amino acid residues distributed on the retinal or the olfactory CNG channel subunits that play a key role in channel regulation. In this review, we will focus on these specific molecular sites of activation and modulation of CNG channels.
Mots-clé
Animals Binding Sites Calcium/metabolism Calmodulin/metabolism Ion Channels/*metabolism Photoreceptors, Vertebrate/*metabolism Smell/physiology Vision/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 12:01
Dernière modification de la notice
03/03/2018 19:33
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