Pharmacokinetics of mycophenolic acid associated with calcineurin inhibitors: long-term monitoring in stable lung recipients with and without cystic fibrosis.
Details
Serval ID
serval:BIB_92D7E12F596A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pharmacokinetics of mycophenolic acid associated with calcineurin inhibitors: long-term monitoring in stable lung recipients with and without cystic fibrosis.
Journal
Journal of Heart and Lung Transplantation
ISSN
1053-2498[print], 1053-2498[linking]
Publication state
Published
Issued date
2003
Volume
22
Number
5
Pages
587-590
Language
english
Abstract
Pharmacologic interactions and absorption disturbances after transplantation may induce serologic fluctuation of immunosuppression and adversely affect outcome. We present data showing that trough levels of mycophenolic acid decreased by 50% during combined mycophenolate mofetil (MMF) and cyclosporine therapy compared with levels during combined MMF and tacrolimus therapy. In addition, cystic fibrosis patients required 30% higher doses of MMF to achieve the therapeutic levels of recipients without cystic fibrosis.
Keywords
Adult, Calcineurin/antagonists & inhibitors, Cyclosporine/pharmacokinetics, Cyclosporine/therapeutic use, Cystic Fibrosis/drug therapy, Cystic Fibrosis/surgery, Dose-Response Relationship, Drug, Drug Interactions, Drug Therapy, Combination, Humans, Immunosuppressive Agents/pharmacokinetics, Immunosuppressive Agents/therapeutic use, Lung Transplantation/immunology, Mycophenolic Acid/analogs & derivatives, Mycophenolic Acid/pharmacokinetics, Tacrolimus/pharmacokinetics, Tacrolimus/therapeutic use
Pubmed
Web of science
Create date
19/02/2010 20:08
Last modification date
20/08/2019 15:55
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