Efficacy of subinhibitory concentration of pefloxacin in preventing experimental Staphylococcus aureus foreign body infection in mice

Détails

ID Serval
serval:BIB_92B51722F39B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Efficacy of subinhibitory concentration of pefloxacin in preventing experimental Staphylococcus aureus foreign body infection in mice
Périodique
Drugs Under Experimental and Clinical Research
Auteur(s)
Carsenti-Etesse  H., Entenza  J., Durant  J., Pradier  C., Mondain  V., Bernard  E., Dellamonica  P.
ISSN
0378-6501 (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
18
Numéro
10
Pages
415-22
Notes
Journal Article
Résumé
Adhesion is the first step leading to colonization and infection of a foreign body (FBI). To assess the ability of a subinhibitory concentration (subMIC) of pefloxacin (P) to prevent such infection, an experimental model was developed in Swiss albino mice. Subcuts of polyurethane catheters (Vygon) were placed in the peritoneal cavity of animals and 24 hours later, different inocula of an adherent strain of Staphylococcus aureus (SA) (MIC of P:0.8 mg/l) were injected i.p. Unexposed SA served as controls. Two days later the removed catheters, blood and spleen specimens were quantitatively cultured for bacterial content and identity. Infection was defined as more than 10 CFU/ml of SA recovered. Significant protection of mice, with lower dissemination, was found with inoculum sizes of 10(5) and 10(6). These results suggest that subMICs of P may confer protection against foreign body infection.
Mots-clé
Animals Bacterial Adhesion Disease Models, Animal Female Foreign Bodies/*complications Mice Pefloxacin/administration & dosage/*therapeutic use Peritoneal Cavity/microbiology Spleen/microbiology Staphylococcal Infections/etiology/microbiology/*prevention & control Staphylococcus aureus/growth & development/pathogenicity
Pubmed
Web of science
Création de la notice
24/01/2008 14:45
Dernière modification de la notice
03/03/2018 19:32
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