Acute hepatitis due to brivudin: a case report.

Détails

ID Serval
serval:BIB_92B3D6512CFD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Acute hepatitis due to brivudin: a case report.
Périodique
Journal of Hepatology
Auteur(s)
Mottu A., Rubbia-Brandt L., Bihl F., Hadengue A., Spahr L.
ISSN
0168-8278
Statut éditorial
Publié
Date de publication
2009
Volume
51
Numéro
5
Pages
967-969
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
BACKGROUND/AIMS: Brivudin is licensed in several European countries for the treatment of herpetic infections, and is considered safe (approximately 1% of patients with transient elevation of liver enzymes) in large multicenter trials. METHODS: We report a case of acute brivudin hepatitis documented with a liver biopsy in detail. RESULTS: Liver biopsy demonstrated acute liver injury with a predominant cytolytic pattern and features suggestive of a drug-induced immunoallergic hepatitis. Elevated ALT levels returned to normal within weeks. CONCLUSIONS: This is the first published case of acute immunoallergic hepatitis due to brivudin.
Mots-clé
Adult, Alanine Transaminase/blood, Antiviral Agents/toxicity, Bilirubin/blood, Bromodeoxyuridine/analogs & derivatives, Bromodeoxyuridine/toxicity, Drug-Induced Liver Injury/blood, Drug-Induced Liver Injury/enzymology, Herpes Simplex/drug therapy, Humans, Male
Pubmed
Web of science
Création de la notice
11/02/2010 17:18
Dernière modification de la notice
03/03/2018 19:32
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