Psoriasis: nouveautés et défis en 2015 [Psoriasis: advances and challenges in 2015]

Details

Serval ID
serval:BIB_927F76EEA451
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Psoriasis: nouveautés et défis en 2015 [Psoriasis: advances and challenges in 2015]
Journal
Revue medicale suisse
Author(s)
Conrad C., Triboulet C., Gilliet M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
01/04/2015
Peer-reviewed
Oui
Volume
11
Number
468
Pages
754,756-758
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Over the course of the last decade advances in the understanding the pathogenesis of psoriasis have resulted in the development of many novel, safe and effective biologics. However, a significant proportion of patients respond inadequately to biologics--defined by failing to respond initially (lack of efficacy) or secondary failure--with diminishing response over time (loss of efficacy). Over the past years insights into molecular and genetic profiles have allowed to better define psoriasis phenotypes and to explain these therapeutic failures. Here we will illustrate these advances, describe the novel therapeutics on the horizon and review the current view of psoriasis as a systemic disease associated with co-morbidities and its important implications for the management of psoriatic patients.
Keywords
Biological Products/therapeutic use, Drug Design, Humans, Phenotype, Psoriasis/drug therapy, Psoriasis/genetics, Psoriasis/pathology, Treatment Failure, Treatment Outcome
Pubmed
Create date
11/11/2016 12:45
Last modification date
24/02/2024 7:34
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