Searching for targets for the systemic therapy of mesothelioma.

Détails

ID Serval
serval:BIB_927822C7CC73
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Searching for targets for the systemic therapy of mesothelioma.
Périodique
Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo
Auteur(s)
Stahel R.A., Weder W., Felley-Bosco E., Petrausch U., Curioni-Fontecedro A., Schmitt-Opitz I., Peters S.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
26
Numéro
8
Pages
1649-1660
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Malignant mesothelioma is an incurable disease associated with asbestos exposure arising in the pleural cavity and less frequently in the peritoneal cavity. Platinum-based combination chemotherapy with pemetrexed is the established standard of care. Multimodality approaches including surgery and radiotherapy are being investigated. Increasing knowledge about the molecular characteristics of mesothelioma had led to the identification of novel potential targets for systemic therapy. Current evidence suggests pathways activated in response to merlin deficiency, including Pi3K/mTOR and the focal adhesion kinase, as well as immunotherapeutic approaches to be most promising. This review elaborates on the rationale behind targeted approaches that have been and are undergoing exploration in mesothelioma and summarizes available clinical results and ongoing efforts to improve the systemic therapy of mesothelioma.
Mots-clé
Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cisplatin/administration & dosage, Everolimus/administration & dosage, Focal Adhesion Protein-Tyrosine Kinases/antagonists & inhibitors, Focal Adhesion Protein-Tyrosine Kinases/metabolism, Humans, Immunotherapy, Lung Neoplasms/drug therapy, Lung Neoplasms/metabolism, Mesothelioma/drug therapy, Mesothelioma/metabolism, Molecular Targeted Therapy/methods, Pemetrexed/administration & dosage, Phosphatidylinositol 3-Kinases/antagonists & inhibitors, Phosphatidylinositol 3-Kinases/metabolism, Pleural Neoplasms/drug therapy, Pleural Neoplasms/metabolism, Protein Kinase Inhibitors/administration & dosage, TOR Serine-Threonine Kinases/antagonists & inhibitors, TOR Serine-Threonine Kinases/metabolism
Pubmed
Web of science
Création de la notice
07/09/2015 15:48
Dernière modification de la notice
03/03/2018 19:32
Données d'usage