A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_92745B75CD5B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning.
Périodique
Nature Communications
Auteur(s)
Saina M., Busengdal H., Sinigaglia C., Petrone L., Oliveri P., Rentzsch F., Benton R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
6
Pages
6243
Langue
anglais
Résumé
Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of GRs (Gustatory receptor-like (Grl) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two Grls in the cnidarian Nematostella vectensis, NvecGrl1 and NvecGrl2, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms. NvecGrl1 transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of NvecGrl1 causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome Grl from the sea urchin Strongylocentrotus purpuratus displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/01/2015 10:28
Dernière modification de la notice
20/08/2019 14:55
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