Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Microcrystals as DAMPs and their role in joint inflammation.
Rheumatology (oxford, England)
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Microcrystals associated with joint diseases, namely monosodium urate, calcium pyrophosphate and basic calcium phosphate, can be considered as 'danger signals' to the innate immune system and provoke inflammation through inflammasome-dependent as well as inflammasome-independent pathways. Direct crystal membrane interactions can also lead to cell activation. The result is the generation of IL-1β and other pro-inflammatory cytokines. The primacy of IL-1β in the case of gouty inflammation has been demonstrated by the efficacy of IL-1 inhibitors in clinical studies. These findings may be relevant to other diseases where crystal formation is found, such as OA and atherosclerosis.
Arthritis/immunology, Arthritis/metabolism, Humans, Immunity, Innate, Inflammasomes/immunology, Inflammasomes/metabolism, Inflammation Mediators/immunology, Inflammation Mediators/metabolism
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