Microcrystals as DAMPs and their role in joint inflammation.

Détails

ID Serval
serval:BIB_925220FB32EE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Microcrystals as DAMPs and their role in joint inflammation.
Périodique
Rheumatology (oxford, England)
Auteur(s)
Busso N., So A.
ISSN
1462-0332 (Electronic)
ISSN-L
1462-0324
Statut éditorial
Publié
Date de publication
2012
Volume
51
Numéro
7
Pages
1154-1160
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
Microcrystals associated with joint diseases, namely monosodium urate, calcium pyrophosphate and basic calcium phosphate, can be considered as 'danger signals' to the innate immune system and provoke inflammation through inflammasome-dependent as well as inflammasome-independent pathways. Direct crystal membrane interactions can also lead to cell activation. The result is the generation of IL-1β and other pro-inflammatory cytokines. The primacy of IL-1β in the case of gouty inflammation has been demonstrated by the efficacy of IL-1 inhibitors in clinical studies. These findings may be relevant to other diseases where crystal formation is found, such as OA and atherosclerosis.
Mots-clé
Arthritis/immunology, Arthritis/metabolism, Humans, Immunity, Innate, Inflammasomes/immunology, Inflammasomes/metabolism, Inflammation Mediators/immunology, Inflammation Mediators/metabolism
Pubmed
Web of science
Création de la notice
16/02/2012 15:52
Dernière modification de la notice
03/03/2018 19:31
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