Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update.

Détails

ID Serval
serval:BIB_92408BDDB65D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mixed Adenoneuroendocrine Carcinomas (MANECs) of the Gastrointestinal Tract: An Update.
Périodique
Cancers
Auteur(s)
La Rosa S., Marando A., Sessa F., Capella C.
ISSN
2072-6694 (Electronic)
ISSN-L
2072-6694
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
4
Numéro
1
Pages
11-30
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublish
Résumé
The systematic application of immunohistochemical techniques to the study of tumors has led to the recognition that neuroendocrine cells occur rather frequently in exocrine neoplasms of the gut. It is now well known that there is a wide spectrum of combinations of exocrine and neuroendocrine components, ranging from adenomas or carcinomas with interspersed neuroendocrine cells at one extreme to classical neuroendocrine tumors with a focal exocrine component at the other. In addition, both exocrine and neuroendocrine components can have different morphological features ranging, for the former, from adenomas to adenocarcinomas with different degrees of differentiation and, for the latter, from well differentiated to poorly differentiated neuroendocrine tumors. However, although this range of combinations of neuroendocrine and exocrine components is frequently observed in routine practice, mixed exocrine-neuroendocrine carcinomas, now renamed as mixed adenoneuroendocrine carcinomas (MANECs), are rare; these are, by definition, neoplasms in which each component represents at least 30% of the lesion. Gastrointestinal MANECs can be stratified in different prognostic categories according to the grade of malignancy of each component. The present paper is an overview of the main clinicopathological, morphological, immunohistochemical and molecular features of this specific rare tumor type.
Pubmed
Open Access
Oui
Création de la notice
06/09/2016 13:10
Dernière modification de la notice
20/08/2019 14:55
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