Childhood adversity: A gateway to multimorbidity in older age?

Détails

Ressource 1Demande d'une copie Sous embargo jusqu'au 01/01/2020.
Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_923BD56F9AD2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Childhood adversity: A gateway to multimorbidity in older age?
Périodique
Archives of gerontology and geriatrics
Auteur(s)
Henchoz Y., Seematter-Bagnoud L., Nanchen D., Büla C., von Gunten A., Démonet J.F., Santos-Eggimann B.
ISSN
1872-6976 (Electronic)
ISSN-L
0167-4943
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
80
Pages
31-37
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Multimorbidity, or co-occurrence of several chronic diseases, has major consequences in terms of function, quality of life and mortality. Recent advances suggest that the aetiology of multimorbidity includes a life-long process. The purpose of this study was to determine the association between childhood adversity and multimorbidity in community-dwelling older adults, and to investigate variation in participants born immediately before, during and at the end of the Second World War.
Participants were 4731 community-dwelling older adults who enrolled in the Lausanne cohort 65+ study (Switzerland) at age 65-70 years in 2004/2009/2014. A baseline questionnaire provided several indicators of childhood adversity including premature birth, food restrictions, child labour, family economic environment, serious illness/accident, and stressful life events. Multimorbidity at age 67-72 years was defined as ≥2 active chronic diseases at the 2-year follow-up questionnaire.
All childhood adversity indicators except premature birth were significantly associated with multimorbidity. Odds ratio (OR) ranged from 1.23 (P = 0.034) for poor family economic environment to 1.74 (P < 0.001) for stressful life events. In a multivariable model adjusted for socioeconomic status, health behaviours and stressful life events in adulthood (>16 years), a history of serious illness/accident (OR = 1.45; P < 0.001) and stressful life events (OR = 1.42; P = 0.001) in childhood remained significantly associated with multimorbidity. Comparisons between cohorts indicated substantial variations in the prevalence of childhood adversity indicators but similar associations with multimorbidity.
There was an independent association between childhood adversity and multimorbidity after age 65. This study encourages a comprehensive life-course perspective to better understand and potentially prevent multimorbidity.
Mots-clé
Aged, Child, Cohort Studies, Female, Health Behavior, Humans, Independent Living, Male, Multimorbidity, Quality of Life, Social Class, Stress, Psychological/complications, Epidemiology, Life-course, Public health
Pubmed
Web of science
Création de la notice
23/10/2018 10:09
Dernière modification de la notice
20/08/2019 14:55
Données d'usage