Impact of smoking on fertility and age of menopause: a population-based assessment.

Détails

Ressource 1Télécharger: Oboni.pdf (821.13 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_923815E7B8F5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impact of smoking on fertility and age of menopause: a population-based assessment.
Périodique
BMJ open
Auteur(s)
Oboni J.B., Marques-Vidal P., Bastardot F., Vollenweider P., Waeber G.
ISSN
2044-6055 (Electronic)
ISSN-L
2044-6055
Statut éditorial
Publié
Date de publication
18/11/2016
Peer-reviewed
Oui
Volume
6
Numéro
11
Pages
e012015
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Studies in patients seeking medically assisted reproduction have shown that smoking reduces fertility, but little information is available in the general population. We assessed the associations between smoking and the number of children, childbearing planning and age at menopause in a representative sample of the population of Lausanne, Switzerland.
Data from 6711 participants (3530 women, age range 35-75 years) collected between 2003 and 2006 and again in 2009 and 2012. Smoking status, number of offsprings and age of menopause were assessed.
Women who currently smoke had significantly less children than former or never smokers: the number of children per women (average±SD) was 1.38±1.05, 1.45±1.07 and 1.576±1.16, respectively (p<0.001). Women who currently smoke had their first child at an earlier age than the others: 26.7±5.2, 27.4±5.4 and 26.9±5.2 years old for current, former and never smokers, respectively, (p=0.01). Similar findings were found for men: number of children per men 1.475±1.16, 1.67±1.13 and 1.55±1.22 for current, former and never smokers, respectively (p<0.001); no difference was found regarding age at the first child. The difference persisted after multivariate adjustment (adjusted for age, body mass index, Caucasian origins, alcohol consumption, caffeinated drinks consumption, educational level, receiving social help and women taking contraceptives) for the age at first child among women. No association was found between Heaviness of Smoking Index and the number of children among current smokers in both genders. Women who smoke had their menopause more than 1 year prior than never-smoking women (48.9±0.2 years compared with 47.8±0.3 years, respectively, p=0.002).
Smoking is associated with an earlier age of having the first child and of menopause among women.

Mots-clé
Adult, Age Factors, Aged, Alcohol Drinking/epidemiology, Diabetes Mellitus/epidemiology, Educational Status, Female, Fertility, Humans, Male, Menopause, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Risk Factors, Smoking/adverse effects, Smoking/epidemiology, Switzerland/epidemiology, EPIDEMIOLOGY, PREVENTIVE MEDICINE, REPRODUCTIVE MEDICINE, TOXICOLOGY
Pubmed
Web of science
Création de la notice
28/11/2016 14:43
Dernière modification de la notice
03/03/2018 19:31
Données d'usage