Distribution of two morphologically distinct subsets of serotoninergic axons in the cerebral cortex of the marmoset

Détails

ID Serval
serval:BIB_9236596D348A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Distribution of two morphologically distinct subsets of serotoninergic axons in the cerebral cortex of the marmoset
Périodique
Journal of Comparative Neurology
Auteur(s)
Hornung  J. P., Fritschy  J. M., Tork  I.
ISSN
0021-9967 (Print)
Statut éditorial
Publié
Date de publication
07/1990
Volume
297
Numéro
2
Pages
165-81
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul 8
Résumé
The serotoninergic innervation of the marmoset (New World monkey, Callithrix jacchus) cerebral cortex has been analyzed by using immunocytochemistry. The use of a sensitive monoclonal antibody against serotonin allowed the visualization of the fine morphology of individual axons. Two types of terminal axons were demonstrated: one has sparse, small, ovoid varicosities (dia. less than 1 micron), and the other has large, spheroidal varicosities (up to 5 microns in dia.), which are more densely clustered. The first type of axon is distributed through all cortical layers, with a characteristic laminar distribution that varies from area to area. The second type of axons was distributed sparsely in all regions but was markedly denser in the frontal and anterior parietal lobes, and in the hippocampal formation. Axons with large varicosities typically surrounded certain cell bodies and proximal dendrites, forming pericellular arrays, or baskets. These morphological specializations were most frequent in the frontal and anterior parietal cortex, where they were found around stellate and horizontal cells in layer I and around stellate and bipolar cells in layer II and III. Similar baskets were also found in the hippocampal formation, mainly along the border between the hilus and the granule cell layer of the dentate gyrus, across the CA4 field, and at each side of the pyramidal cell layer of the CA3 regions. The distribution and cellular morphology of the cell surrounded by the 5-HT basket fibres were suggestive of a subpopulation of interneurons, possibly GABAergic and/or peptidergic. In agreement with previous reports on the innervation of the cerebral cortex of other mammalian species, the marmoset cerebral cortex is innervated by two separate subsystems of serotoninergic axons. One of these may have a strong and specific influence on the cortical inhibitory circuitry, via relay through cortical interneurons.
Mots-clé
Animals Axons/*metabolism/ultrastructure Callitrichinae/anatomy & histology/*metabolism Cerebral Cortex/*metabolism/ultrastructure Immunohistochemistry Nerve Fibers/metabolism/ultrastructure Serotonin/diagnostic use/*metabolism Tissue Distribution
Pubmed
Web of science
Création de la notice
24/01/2008 15:22
Dernière modification de la notice
03/03/2018 19:31
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