Article: article from journal or magazin.
Preferential binding of mouse mammary tumor virus to B lymphocytes.
Journal of Virology
Mouse mammary tumor virus (MMTV) has been shown to preferentially infect B lymphocytes in vivo. We have used recombinant envelope-coated fluospheres and highly purified MMTV particles to study the distribution of the viral receptors on fresh mouse lymphocytes. A preferential dose-dependent binding to B lymphocytes was observed which could be competed with neutralizing antibodies. In contrast, T-lymphocyte binding remained at background levels. These results strongly suggest a higher density of viral receptor molecules on B lymphocytes than on T lymphocytes and correlate with the preferential initial infection of B lymphocytes observed in vivo.
Animals, Antigens, Viral, Tumor/genetics, Antigens, Viral, Tumor/isolation & purification, B-Lymphocytes/cytology, B-Lymphocytes/metabolism, Cells, Cultured, Mammary Tumor Virus, Mouse/metabolism, Mice, Mice, Inbred BALB C, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/isolation & purification, Spleen/cytology, T-Lymphocytes/cytology, T-Lymphocytes/metabolism
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