Identification of novel and cell type enriched cofactors of the transcription activation domain of RelA (p65 NF-kappaB).

Détails

ID Serval
serval:BIB_922A43E70F8C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Identification of novel and cell type enriched cofactors of the transcription activation domain of RelA (p65 NF-kappaB).
Périodique
Journal of proteome research
Auteur(s)
Owen H.R., Quadroni M., Bienvenut W., Buerki C., Hottiger M.O.
ISSN
1535-3893
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
4
Numéro
4
Pages
1381-1390
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
RelA (NF-kappaB) is a transcription factor inducible by distinct stimuli in many different cell types. To find new cell type specific cofactors of NF-kappaB dependent transcription, we isolated RelA transcription activation domain binding proteins from the nuclear extracts of three different cell types. Analysis by electrophoresis and liquid chromatography tandem mass spectrometry identified several novel putative molecular partners. Some were strongly enriched in the complex formed from the nuclear extracts of specific cell types.
Mots-clé
Animals, Cell Line, DNA-Binding Proteins, Databases, Protein, Humans, Mass Spectrometry, Molecular Sequence Data, NF-kappa B, Nuclear Proteins, Promoter Regions, Genetic, Protein Binding, Protein Interaction Mapping, Protein Structure, Tertiary, Protein Subunits, Recombinant Fusion Proteins, Reproducibility of Results, Trans-Activators, Transcription Factor RelA, Transcriptional Activation
Pubmed
Web of science
Création de la notice
24/01/2008 16:46
Dernière modification de la notice
03/03/2018 19:30
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