What is the true clinical relevance of Simkania negevensis and other emerging Chlamydiales members?
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_92241296F0A3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
What is the true clinical relevance of Simkania negevensis and other emerging Chlamydiales members?
Journal
New microbes and new infections
ISSN
2052-2975 (Print)
ISSN-L
2052-2975
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
23
Pages
1-5
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
<i>Waddlia</i> <i>chondrophila</i> and <i>Simkania negevensis</i> are emerging <i>Chlamydia-</i> related bacteria. Similar to the pathogenic organisms <i>Chlamydia pneumoniae</i> and <i>Chlamydia trachomatis,</i> these emerging bacteria are implicated in human genital infections and respiratory diseases. We used a screening strategy based on a newly developed <i>S. negevensis</i> -specific quantitative real-time PCR (qPCR) and a pan- <i>Chlamydiales</i> qPCR. We could not detect <i>S. negevensis</i> in 458 respiratory, genitourinary, cardiac and hepatic samples tested. One urethral swab was positive for <i>W. chondrophila.</i> We observed a low prevalence of <i>Chlamydiales</i> in respiratory samples (1/200, 0.5%), which suggests that <i>C. pneumoniae</i> is an uncommon respiratory pathogen. Furthermore, we screened 414 human serum samples from Switzerland, England and Israel and observed a low prevalence (<1%) of exposure to <i>S. negevensis.</i> Conversely, humans were commonly exposed to <i>W. chondrophila,</i> with seroprevalences ranging from 8.6% to 32.5%. <i>S. negevensis</i> is not a clinically relevant pathogen, but further research investigating the role of <i>W. chondrophila</i> is needed.
Keywords
Chlamydiae, emerging, intracellular bacteria, pathogen, pneumonia
Pubmed
Open Access
Yes
Create date
26/04/2018 17:38
Last modification date
20/08/2019 15:55