What is the true clinical relevance of Simkania negevensis and other emerging Chlamydiales members?

Détails

Ressource 1Télécharger: 29692903_BIB_92241296F0A3.pdf (129.80 [Ko])
Etat: Serval
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_92241296F0A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
What is the true clinical relevance of Simkania negevensis and other emerging Chlamydiales members?
Périodique
New microbes and new infections
Auteur(s)
Vouga M., Kebbi-Beghdadi C., Liénard J., Baskin L., Baud D., Greub G.
ISSN
2052-2975 (Print)
ISSN-L
2052-2975
Statut éditorial
Publié
Date de publication
05/2018
Peer-reviewed
Oui
Volume
23
Pages
1-5
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
<i>Waddlia</i>   <i>chondrophila</i> and <i>Simkania negevensis</i> are emerging <i>Chlamydia-</i> related bacteria. Similar to the pathogenic organisms <i>Chlamydia pneumoniae</i> and <i>Chlamydia trachomatis,</i> these emerging bacteria are implicated in human genital infections and respiratory diseases. We used a screening strategy based on a newly developed <i>S. negevensis</i> -specific quantitative real-time PCR (qPCR) and a pan- <i>Chlamydiales</i> qPCR. We could not detect <i>S. negevensis</i> in 458 respiratory, genitourinary, cardiac and hepatic samples tested. One urethral swab was positive for <i>W. chondrophila.</i> We observed a low prevalence of <i>Chlamydiales</i> in respiratory samples (1/200, 0.5%), which suggests that <i>C. pneumoniae</i> is an uncommon respiratory pathogen. Furthermore, we screened 414 human serum samples from Switzerland, England and Israel and observed a low prevalence (<1%) of exposure to <i>S. negevensis.</i> Conversely, humans were commonly exposed to <i>W. chondrophila,</i> with seroprevalences ranging from 8.6% to 32.5%. <i>S. negevensis</i> is not a clinically relevant pathogen, but further research investigating the role of <i>W. chondrophila</i> is needed.

Mots-clé
Chlamydiae, emerging, intracellular bacteria, pathogen, pneumonia
Pubmed
Open Access
Oui
Création de la notice
26/04/2018 17:38
Dernière modification de la notice
29/05/2019 7:09
Données d'usage