HIV and Aging - Perhaps Not as Dramatic as We Feared?

Détails

ID Serval
serval:BIB_92146D8F7DD2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
HIV and Aging - Perhaps Not as Dramatic as We Feared?
Périodique
Gerontology
Auteur(s)
Engel T., Raffenberg M., Marzolini C., Cavassini M., Kovari H., Hasse B., Tarr P.E.
ISSN
1423-0003 (Electronic)
ISSN-L
0304-324X
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
64
Numéro
5
Pages
446-456
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. The aims of this viewpoint paper are to summarize recent data and to examine the possibility that the problem of aging-related morbidity in HIV might not be as dramatic as previously believed.
Mots-clé
AIDS Dementia Complex/etiology, AIDS-Associated Nephropathy/etiology, Adult, Aged, Aging, Antiretroviral Therapy, Highly Active/adverse effects, Atherosclerosis/complications, Atherosclerosis/diagnostic imaging, Body Composition, Cardiovascular Diseases/complications, Drug Interactions, Fractures, Bone/complications, Frailty/complications, HIV Infections/complications, HIV Infections/drug therapy, HIV Infections/mortality, Humans, Life Expectancy/trends, Male, Metabolic Diseases/etiology, Middle Aged, Risk Factors, Telomere Homeostasis, Comedications, Comorbidities, Drug interactions, Frailty, HIV, Polypharmacy
Pubmed
Web of science
Création de la notice
23/07/2018 17:25
Dernière modification de la notice
15/01/2019 7:26
Données d'usage