Overweight and obesity in adult patients with phenylketonuria: a systematic review.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_920FF2B6A864
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Overweight and obesity in adult patients with phenylketonuria: a systematic review.
Journal
Orphanet journal of rare diseases
Author(s)
Tankeu A.T., Pavlidou D.C., Superti-Furga A., Gariani K., Tran C.
ISSN
1750-1172 (Electronic)
ISSN-L
1750-1172
Publication state
Published
Issued date
22/02/2023
Peer-reviewed
Oui
Volume
18
Number
1
Pages
37
Language
english
Notes
Publication types: Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Excess weight is a rising concern in patients with phenylketonuria (PKU). It is commonly observed in children and adolescents with PKU; but data on adults are inconsistent. This review aims to summarize available data on excess weight in adult PKU individuals.
We conducted a systematic search of literature in English, from inception to October 2021, on PubMed and Embase to identify articles on overweight and obesity in adult PKU patients. Prevalence of overweight and obesity, body mass index (BMI) and gender differences were the outcomes of interest.
Of 260 articles identified, only 8 fulfilled quality criteria for inclusion after screening of titles, abstracts and full texts. The mean BMI of adult PKU patients in these studies ranged from 26 ± 5.4 to 30.3 ± 1.8 kg/m <sup>2</sup> . When compared to matched controls, adult PKU patients had higher BMI and higher prevalence of obesity. However, results were inconsistent when PKU adults were compared to the general population. The prevalence of obesity in the included studies varied widely between 4.5% up to 72% in individual studies. Obesity was 2-3 times more frequent in female PKU patients.
Excess weight is frequent in adult PKU patients, especially in females, even if the difference with the general population is debatable. The heterogeneity of the studies makes it difficult to interpret the results and the factors that contribute to obesity. Content of the diet, psychological status, diet-associated disordered eating, patient's social environment and lifestyle are listed as potentials contributors to excess weight in PKU adult population. Further studies are needed to better elucidate this question. In the meantime, weight control and healthy eating habits should be considered in the management and follow-up of these patients.
Keywords
Child, Adolescent, Humans, Adult, Female, Overweight/psychology, Obesity/epidemiology, Phenylketonurias, Body Mass Index, Diet, Obesity, Overweight, Phenylketonuria
Pubmed
Web of science
Open Access
Yes
Create date
27/02/2023 17:24
Last modification date
21/04/2023 6:13
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