Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography.

Details

Serval ID
serval:BIB_91EA3F4809F9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography.
Journal
Annals of Neurology
Author(s)
Leenders K.L., Poewe W.H., Palmer A.J., Brenton D.P., Frackowiak R.S.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
1986
Volume
20
Number
2
Pages
258-262
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The brain uptake of L-[18F]fluorodopa was measured by positron emission tomography in a healthy male volunteer both under fasting conditions and during intravenous amino acid loading. A significant reduction of tracer uptake into the brain was demonstrated with amino acid loading. This finding represents the first direct evidence for competition between L-dopa and other amino acids for uptake across the blood-brain barrier obtained in vivo in a human subject. It underlines the possible importance of interference by dietary amino acids with the therapeutic actions of L-dopa in Parkinson's disease.
Keywords
Adult, Amino Acids/pharmacology, Blood-Brain Barrier, Brain/metabolism, Corpus Striatum/metabolism, Depression, Chemical, Dihydroxyphenylalanine/analogs & derivatives, Dihydroxyphenylalanine/metabolism, Humans, Male, Tomography, Emission-Computed
Pubmed
Web of science
Create date
08/10/2011 15:04
Last modification date
20/08/2019 14:55
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