Article: article from journal or magazin.
Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography.
Annals of Neurology
Publication types: Journal ArticlePublication Status: ppublish
The brain uptake of L-[18F]fluorodopa was measured by positron emission tomography in a healthy male volunteer both under fasting conditions and during intravenous amino acid loading. A significant reduction of tracer uptake into the brain was demonstrated with amino acid loading. This finding represents the first direct evidence for competition between L-dopa and other amino acids for uptake across the blood-brain barrier obtained in vivo in a human subject. It underlines the possible importance of interference by dietary amino acids with the therapeutic actions of L-dopa in Parkinson's disease.
Adult, Amino Acids/pharmacology, Blood-Brain Barrier, Brain/metabolism, Corpus Striatum/metabolism, Depression, Chemical, Dihydroxyphenylalanine/analogs & derivatives, Dihydroxyphenylalanine/metabolism, Humans, Male, Tomography, Emission-Computed
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