Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance.

Détails

ID Serval
serval:BIB_91DE54ABA4A6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance.
Périodique
International Journal of Cancer. Journal International Du Cancer
Auteur(s)
Singh A.K., Arya R.K., Maheshwari S., Singh A., Meena S., Pandey P., Dormond O., Datta D.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
136
Numéro
9
Pages
1991-2000
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate. Recently, a path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of CSCs in brain, skin and intestinal tumors using lineage-tracing and thus strengthens the CSC concept; even though certain fundamental caveats are always associated with lineage-tracing approach. In principle, the CSC hypothesis proposes that similar to normal stem cells, CSCs maintain self renewal and multilineage differentiation property and are found at the central echelon of cellular hierarchy present within tumors. However, these cells differ from their normal counterpart by maintaining their malignant potential, alteration of genomic integrity, epigenetic identity and the expression of specific surface protein profiles. As CSCs are highly resistant to chemotherapeutics, they are thought to be a crucial factor involved in tumor relapse and superficially appear as the ultimate therapeutic target. However, even that is not the end; further complication is attributed by reports of bidirectional regeneration mechanism for CSCs, one from their self-renewal capability and another from the recently proposed concept of dynamic equilibrium between CSCs and non-CSCs via their interconversion. This phenomenon has currently added a new layer of complexity in understanding the biology of tumor heterogeneity. In-spite of its associated controversies, this area has rapidly emerged as the center of attention for researchers and clinicians, because of the conceptual framework it provides towards devising new therapies.
Mots-clé
Animals, Cell Differentiation/physiology, Humans, Neoplasms/pathology, Neoplastic Stem Cells/pathology
Pubmed
Web of science
Création de la notice
13/08/2014 14:07
Dernière modification de la notice
03/03/2018 19:29
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