Evolution of Acid-Sensing Olfactory Circuits in Drosophilids.

Détails

ID Serval
serval:BIB_91CF6E8DDDD6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolution of Acid-Sensing Olfactory Circuits in Drosophilids.
Périodique
Neuron
Auteur(s)
Prieto-Godino L.L., Rytz R., Cruchet S., Bargeton B., Abuin L., Silbering A.F., Ruta V., Dal Peraro M., Benton R.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
08/02/2017
Peer-reviewed
Oui
Volume
93
Numéro
3
Pages
661-676.e6
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Morinda citrifolia fruit-with its generalist cousins D. melanogaster and D. simulans. We show that D. sechellia exhibits derived odor-evoked attraction and physiological sensitivity to the abundant Morinda volatile hexanoic acid and characterize how the responsible sensory receptor (the variant ionotropic glutamate receptor IR75b) and attraction-mediating circuit have evolved. A single amino acid change in IR75b is sufficient to recode it as a hexanoic acid detector. Expanded representation of this sensory pathway in the brain relies on additional changes in the IR75b promoter and trans-acting loci. By contrast, higher-order circuit adaptations are not apparent, suggesting conserved central processing. Our work links olfactory ecology to structural and regulatory genetic changes influencing nervous system anatomy and function.

Mots-clé
Animals, Biological Evolution, Caproates/metabolism, Drosophila, Drosophila Proteins/genetics, Drosophila Proteins/metabolism, Drosophila melanogaster, Drosophila simulans, Evolution, Molecular, Fruit, Morinda/chemistry, Mutation, Neurons/metabolism, Odorants, Receptors, Ionotropic Glutamate/genetics, Receptors, Ionotropic Glutamate/metabolism, Receptors, Odorant/genetics, Receptors, Odorant/metabolism, Smell/genetics, Drosophila sechellia, adaptation, behavior, evolution, ionotropic glutamate receptor, neural circuit, neuron, odorant receptor, olfaction
Pubmed
Web of science
Création de la notice
30/01/2017 17:34
Dernière modification de la notice
20/08/2019 14:54
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