Article: article from journal or magazin.
Clonal analysis of the BALB/c T cell proliferative response to apo beef cytochrome c.
Journal of Immunology
Murine T cell clones that proliferated specifically in response to the protein antigen apo cytochrome c were derived and maintained in continuous culture. Two distinct clonotypes were observed with respect to the proliferative responses observed when a variety of peptides prepared from several species of cytochrome c were tested. These 2 clonotypes appeared to recognize 2 different regions in the cytochrome c molecule. Only 1 of the 2 clonotypes tested demonstrated helper cell activity for antibody formation in vitro.
Animals, Antibody Formation, Antibody-Producing Cells/immunology, Apoproteins/immunology, Cattle, Clone Cells/immunology, Cytochrome c Group/pharmacology, Hemolytic Plaque Technique, Horses, Lymph Nodes/immunology, Lymphocyte Activation, Mice, Mice, Inbred BALB C, T-Lymphocytes/immunology, Trinitrobenzenes/immunology
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