Prognostic factors in colorectal cancer
Details
Serval ID
serval:BIB_91A312EA95F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic factors in colorectal cancer
Journal
Oncology Reports
ISSN
1021-335X (Print)
Publication state
Published
Issued date
04/1999
Volume
6
Number
2
Pages
409-14
Notes
Journal Article --- Old month value: Mar-Apr
Abstract
Prognosis of patients after colorectal cancer resection is predominantly influenced by the extent of local tumour growth and the presence or absence of nodal or distant metastasis. However, many factors have been used to generate numerous classification systems, leading to some debate and confusion. The effects on survival of 7 clinical and pathological parameters were reviewed in 801 consecutive patients operated upon with locally curative intent for colorectal cancer over a ten-year period. Age less than 50 or more than 70 years, poor cellular differentiation, high mucous secretion by tumour cells and Dukes' staging were the parameters significantly correlated to poor overall survival (p<0.001 for each). The Cox's regression analysis identified the same parameters as independent prognostic factors. The value of age as a prognostic factor remains debatable, but the other three parameters must be considered when evaluating prognosis after curative surgery for colorectal cancer and when considering adjuvant therapy.
Keywords
Adult
Age Factors
Aged
Aged, 80 and over
Colorectal Neoplasms/mortality/*pathology/surgery
Confidence Intervals
Female
Follow-Up Studies
Hospitals, University
Humans
Male
Medical Records
Middle Aged
Neoplasm Staging
Prognosis
Regression Analysis
Retrospective Studies
Sex Factors
Survival Analysis
Switzerland
Time Factors
Pubmed
Web of science
Create date
28/01/2008 9:56
Last modification date
20/08/2019 15:54