Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.

Détails

ID Serval
serval:BIB_919CC4A77FE2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Périodique
Nature communications
Auteur(s)
Collins S.C., Mikhaleva A., Vrcelj K., Vancollie V.E., Wagner C., Demeure N., Whitley H., Kannan M., Balz R., Anthony LFE, Edwards A., Moine H., White J.K., Adams D.J., Reymond A., Lelliott C.J., Webber C., Yalcin B.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
01/08/2019
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
3465
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse lines and identify 198 genes whose disruptions yield NeuroAnatomical Phenotypes (NAPs), mostly affecting structures implicated in brain connectivity. Groups of functionally similar NAP genes participate in pathways involving the cytoskeleton, the cell cycle and the synapse, display distinct fetal and postnatal brain expression dynamics and importantly, their disruption can yield convergent phenotypic patterns. 17% of human unique orthologues of mouse NAP genes are known loci for cognitive dysfunction. The remaining 83% constitute a vast pool of genes newly implicated in brain architecture, providing the largest study of mouse NAP genes and pathways. This offers a complementary resource to human genetic studies and predict that many more genes could be involved in mammalian brain morphogenesis.
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/08/2019 16:17
Dernière modification de la notice
21/08/2019 6:32
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