Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers.

Détails

ID Serval
serval:BIB_9193B5A03A12
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers.
Périodique
International journal of legal medicine
Auteur(s)
Aljakna A., Fracasso T., Sabatasso S.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
03/2018
Peer-reviewed
Oui
Volume
132
Numéro
2
Pages
425-438
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Diagnosing early myocardial ischemia (the initial 4 to 6 h after interruption of blood flow to part of the myocardium) remains a challenge for clinical and forensic pathologists. Several immunohistochemical markers have been proposed for improving postmortem detection of early myocardial ischemia; however, no single marker appears to be both sufficiently specific as well as sensitive. This review summarizes the diverse categories of molecular tissue markers that have been investigated in human autopsy samples with acute myocardial infarction as well as in the well-established and widely used in vivo animal model of early myocardial ischemia (permanent ligation of the coronary artery). Recently identified markers appearing during the initial 2 h of myocardial ischemia are highlighted. Among them, only six were tested for specificity (C5b-9, hypoxia-inducible factor 1-alpha, vascular endothelial growth factor, heart fatty acid binding protein, connexin 43, and JunB). Despite the discovery of several potentially promising markers (in terms of early expression and specificity), many of them remain to be tested and validated for application in routine diagnostics in clinical and forensic pathology. In particular, research investigating the postmortem stability of these markers is required before any might be implemented into routine diagnostics. Establishing a standardized panel of immunohistochemical markers may be more useful for improving sensitivity and specificity than searching for a single marker.

Mots-clé
Acute myocardial infarction, Coronary artery ligation, Early myocardial ischemia, Marker, Pathology, Sudden cardiac death
Pubmed
Web of science
Création de la notice
30/01/2018 9:57
Dernière modification de la notice
03/03/2018 19:29
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