Geometric control of the cell cycle.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_918B2853B9FA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Geometric control of the cell cycle.
Périodique
Cell Cycle
Auteur(s)
Martin S.G.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
8
Numéro
22
Pages
3643-3647
Langue
anglais
Résumé
How do cells sense their own size and shape? And how does this information regulate progression of the cell cycle? Our group, in parallel to that of Paul Nurse, have recently demonstrated that fission yeast cells use a novel geometry-sensing mechanism to couple cell length perception with entry into mitosis. These rod-shaped cells measure their own length by using a medially-placed sensor, Cdr2, that reads a protein gradient emanating from cell tips, Pom1, to control entry into mitosis. Budding yeast cells use a similar molecular sensor to delay entry into mitosis in response to defects in bud morphogenesis. Metazoan cells also modulate cell proliferation in response to their own shape by sensing tension. Here I discuss the recent results obtained for the fission yeast system and compare them to the strategies used by these other organisms to perceive their own morphology.
Mots-clé
Cell Cycle/physiology, Models, Biological, Morphogenesis/physiology, Protein-Serine-Threonine Kinases/physiology, Schizosaccharomyces/cytology, Schizosaccharomyces pombe Proteins/physiology, Species Specificity
Pubmed
Web of science
Création de la notice
25/01/2010 11:20
Dernière modification de la notice
03/03/2018 19:29
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