Associations of Urinary Caffeine and Caffeine Metabolites With Arterial Stiffness in a Large Population-Based Study.

Détails

ID Serval
serval:BIB_9160FD0FD82A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Associations of Urinary Caffeine and Caffeine Metabolites With Arterial Stiffness in a Large Population-Based Study.
Périodique
Mayo Clinic proceedings
Auteur(s)
Ponte B., Pruijm M., Ackermann D., Ehret G., Ansermot N., Staessen J.A., Vogt B., Pechère-Bertschi A., Burnier M., Martin P.Y., Eap C.B., Bochud M., Guessous I.
ISSN
1942-5546 (Electronic)
ISSN-L
0025-6196
Statut éditorial
Publié
Date de publication
05/2018
Peer-reviewed
Oui
Volume
93
Numéro
5
Pages
586-596
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
To assess the influence of caffeine on arterial stiffness by exploring the association of urinary excretion of caffeine and its related metabolites with pulse pressure (PP) and pulse wave velocity (PWV).
Families were randomly selected from the general population of 3 Swiss cities from November 25, 2009, through April 4, 2013. Pulse pressure was defined as the difference between the systolic and diastolic blood pressures obtained by 24-hour ambulatory monitoring. Carotid-femoral PWV was determined by applanation tonometry. Urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured in 24-hour urine collections. Multivariate linear and logistic mixed models were used to explore the associations of quartiles of urinary caffeine and metabolite excretions with PP, high PP, and PWV.
We included 863 participants with a mean ± SD age of 47.1±17.6 years, 24-hour PP of 41.9±9.2 mm Hg, and PWV of 8.0±2.3 m/s. Mean (SE) brachial PP decreased from 43.5 (0.5) to 40.5 (0.6) mm Hg from the lowest to the highest quartiles of 24-hour urinary caffeine excretion (P<.001). The odds ratio (95% CI) of high PP decreased linearly from 1.0 to 0.52 (0.31-0.89), 0.38 (0.22-0.65), and 0.31 (0.18-0.55) from the lowest to the highest quartile of 24-hour urinary caffeine excretion (P<.001). Mean (SE) PWV in the highest caffeine excretion quartile was significantly lower than in the lowest quartile (7.8 [0.1] vs 8.1 [0.1] m/s; P=.03). Similar associations were found for paraxanthine and theophylline, whereas no associations were found with theobromine.
Urinary caffeine, paraxanthine, and theophylline excretions were associated with decreased parameters of arterial stiffness, suggesting a protective effect of caffeine intake beyond its blood pressure-lowering effect.
Mots-clé
Adult, Biomarkers/urine, Blood Pressure, Caffeine/metabolism, Caffeine/urine, Circadian Rhythm/physiology, Female, Heart Ventricles/metabolism, Humans, Male, Middle Aged, Vascular Stiffness
Pubmed
Web of science
Création de la notice
22/03/2018 19:54
Dernière modification de la notice
16/04/2019 13:38
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