Classification des leucémies aiguës par les marqueurs de surface et corrélation avec le diagnostic morphologique résultats sur 111 cas

Détails

ID Serval
serval:BIB_914BCAD41666
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Classification des leucémies aiguës par les marqueurs de surface et corrélation avec le diagnostic morphologique résultats sur 111 cas
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
von Fliedner V., Carrel S., Morell A., Heumann D., Losa G., Hirt A., Jeannet M., Mach J.P., Cruchaud A.
ISSN
0036-7672 (Print)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
1981
Volume
111
Numéro
41
Pages
1524-1526
Langue
français
Notes
[Classification of acute leukemias by surface markers and correlation with the morphological diagnosis. Results of 111 cases].
Résumé
111 patients with acute leukemia, including 29 children, were classified according to the surface markers and cytochemistry of their blasts. The acute leukemias were separated into two majors groups (lymphoid and non-lymphoid) depending on the presence or absence of specific lymphoid markers. On the basis of these criteria a correlation of 94% with the hematological diagnosis was obtained. Acute lymphoblastic leukemia (ALL) was divisible into three sub-groups: 11 cases expressing T-cell specific markers were classified as T-ALL and 33 cases expressing the common ALL antigen (CALLA) as c-ALL. 18 of the latter expressed an additional marker, DSA (Daudi surface antigen), splitting c-ALL cases in two subgroups. Cytochemistry of the cases lacking specific surface markers (n = 67) served to diagnose 41 acute myeloid leukemia (AML) cases and 8 monoblastic leukemias. The remaining 18 cases could not be classified. The presence of absence of HLD-DR (Ia) antigens served to subdivide AML into two major subgroups. The prognostic significance of these new diagnostic splits is under active study.
Mots-clé
Acute Disease, Antigens, Surface/analysis, B-Lymphocytes/immunology, HLA Antigens/analysis, Humans, Leukemia/classification, Leukemia/immunology, Receptors, Immunologic/analysis, Rosette Formation, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
25/04/2013 14:20
Dernière modification de la notice
03/03/2018 19:28
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