Role of nitric oxide in genotoxicity: implication for carcinogenesis.

Détails

ID Serval
serval:BIB_9122
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Role of nitric oxide in genotoxicity: implication for carcinogenesis.
Périodique
Cancer Metastasis Reviews
Auteur(s)
Felley-Bosco E.
ISSN
0167-7659 (Print)
ISSN-L
0167-7659
Statut éditorial
Publié
Date de publication
1998
Volume
17
Numéro
1
Pages
25-37
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Reactive oxygen species can initiate carcinogenesis by virtue of their capacity to react with DNA and cause mutations. Recently, it has been suggested that nitric oxide (NO) and its derivatives produced in inflamed tissues could contribute to the carcinogenesis process. Genotoxicity of NO follows its reaction with oxygen and superoxide. It can be due either to direct DNA damage or indirect DNA damage. Direct damage includes DNA base deamination, peroxynitrite-induced adducts formation and single strand breaks in the DNA. Indirect damage is due to the interaction of NO reactive species with other molecules such as amines, thiols and lipids. The efficiency of one pathway or another might depend on the cellular antioxidant status or the presence of free metals.
Mots-clé
Animals, DNA Damage, Humans, Neoplasms/genetics, Nitric Oxide/metabolism, Nitric Oxide/toxicity
Pubmed
Web of science
Création de la notice
19/11/2007 13:47
Dernière modification de la notice
03/03/2018 19:27
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