HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.

Détails

Ressource 1Télécharger: s41467-017-00182-7.pdf (2978.23 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_910F88CBC37F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.
Périodique
Nature Communications
Auteur(s)
Ferrari A., Longo R., Fiorino E., Silva R., Mitro N., Cermenati G., Gilardi F., Desvergne B., Andolfo A., Magagnotti C., Caruso D., Fabiani E., Hiebert S.W., Crestani M.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
8
Numéro
1
Pages
93
Langue
anglais
Résumé
White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellular energy metabolism, but their role in white adipose tissue physiology remains incompletely understood. Here we show that histone deacetylase 3 (HDAC3) regulates WAT metabolism and function. Selective ablation of Hdac3 in fat switches the metabolic signature of WAT by activating a futile cycle of de novo fatty acid synthesis and β-oxidation that potentiates WAT oxidative capacity and ultimately supports browning. Specific ablation of Hdac3 in adipose tissue increases acetylation of enhancers in Pparg and Ucp1 genes, and of putative regulatory regions of the Ppara gene. Our results unveil HDAC3 as a regulator of WAT physiology, which acts as a molecular brake that inhibits fatty acid metabolism and WAT browning.Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.

Mots-clé
Adipocytes/physiology, Adipose Tissue, Brown/physiology, Adipose Tissue, White/physiology, Animals, Cell Line, Diet, High-Fat, Gene Expression Regulation/physiology, Gene Silencing, Histone Deacetylases/genetics, Histone Deacetylases/metabolism, Lipid Metabolism, Male, Mice, Mice, Knockout
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/08/2017 11:17
Dernière modification de la notice
08/05/2019 22:00
Données d'usage