MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models.

Détails

ID Serval
serval:BIB_90EE6DBB970E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
MRS studies of neuroenergetics and glutamate/glutamine exchange in rats: Extensions to hyperammonemic models.
Périodique
Analytical biochemistry
Auteur(s)
Lanz B., Rackayova V., Braissant O., Cudalbu C.
ISSN
1096-0309 (Electronic)
ISSN-L
0003-2697
Statut éditorial
Publié
Date de publication
15/07/2017
Peer-reviewed
Oui
Volume
529
Pages
245-269
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
In vivo Magnetic Resonance Spectroscopy is a useful tool to characterize brain biochemistry as well as its alteration in a large number of major central nervous system diseases. The present review will focus on the study of the glutamate-glutamine cycle, an important biochemical pathway in excitatory neurotransmission, analyzed using in vivo MRS of different accessible nuclei: (1)H, (13)C, (15)N and (31)P. The different methodological aspects of data acquisition, processing and absolute quantification of the MRS data for each nucleus will be presented, as well as the description of the mathematical modeling approach to interpret the MRS measurements in terms of biochemical kinetics. The unique advantages of MRS, especially its non-invasive nature enabling longitudinal monitoring of brain disease progression and/or effect of treatment is illustrated in the particular context of hyperammonemic disorders with a specific focus on animal models. We review the current possibilities given by in vivo MRS to investigate some of the molecular mechanisms involved in hyperammonemic disorders and to give a better understanding of the process of development of hepatic encephalopathy, a severe neuropsychiatric disorder that frequently accompanies liver disease.

Mots-clé
Animals, Brain/metabolism, Glutamic Acid/metabolism, Glutamine/metabolism, Hyperammonemia/diagnosis, Hyperammonemia/metabolism, Magnetic Resonance Imaging/methods, Magnetic Resonance Spectroscopy/methods, Models, Biological, Rats, Brain metabolism, Glutamate/glutamine cycle, Hyperammonemia, In vivo magnetic resonance spectroscopy, Neuroenergetics
Pubmed
Web of science
Création de la notice
10/07/2017 15:33
Dernière modification de la notice
20/08/2019 15:54
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