Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry

Details

Serval ID
serval:BIB_90D84573B586
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry
Journal
Molecular Neurobiology
Author(s)
Winsky-Sommerer Raphaëlle, Boutrel Benjamin, Lecea Luis de
ISSN
0893-7648
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
32
Number
3
Pages
285-294
Notes
SAPHIRID:62566
Abstract
The hypocretins (also know as orexins) are two neuropeptides now commonly described as critical components for maintaining and regulating the stability of arousal. Several lines of evidence have raised the hypothesis that hypocretin-producing neurons are part of the circuitries that mediate the hypothalamic response to acute stress. New data indicate that the corticotrophin-releasing factor (CRF) peptidergic system directly innervates hypocretin-expressing neurons. CRF depolarizes hypocretin neurons, and this effect is blocked by a CRF-R1 antagonist. Furthermore, activation of hypocretinergic neurons by stress is impaired in CRF-R1 knockout mice. These data suggest that CRF-R1 receptor mediates the stress-induced activation of the hypocretinergic system. A significant amount of evidence also indicates that hypocretin cells connect reciprocally to the CRF system. We propose that upon stressor stimuli, CRF activates the hypocretin system, which relays these signals to brain stem nuclei involved in the modulation of arousal as well as to the extended amygdala, a structure involved in the negative motivational state that drives addiction.
Pubmed
Web of science
Create date
11/03/2008 14:07
Last modification date
20/08/2019 14:54
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