Mechanisms of action of beta-glucan in postprandial glucose metabolism in healthy men.

Détails

ID Serval
serval:BIB_90B9ABD725BF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mechanisms of action of beta-glucan in postprandial glucose metabolism in healthy men.
Périodique
European Journal of Clinical Nutrition
Auteur(s)
Battilana P., Ornstein K., Minehira K., Schwarz J.M., Acheson K., Schneiter P., Burri J., Jéquier E., Tappy L.
ISSN
0954-3007
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
55
Numéro
5
Pages
327-333
Langue
anglais
Notes
Journal Article --- Old month value: May
Résumé
OBJECTIVE: To assess whether beta-glucan (which is fermented in the colon) lowers postprandial glucose concentrations through mechanisms distinct from a delayed carbohydrate absorption and inhibits de novo lipogenesis. DESIGN: Administration of frequent small meals each hour over 9 h allows a rate of intestinal absorption to be reached which is independent of a delayed absorption. A group of 10 healthy men received either an isoenergetic diet containing 8.9 g/day beta-glucan or without beta-glucan for 3 days. On the third day, the diet was administered as fractioned meals ingested every hour for 9 h. SETTING: Laboratory for human metabolic investigations. SUBJECTS: Ten healthy male volunteers. MAIN OUTCOME MEASURES: Plasma glucose and insulin concentrations, glucose kinetics, glucose oxidation, de novo lipogenesis. RESULTS: On the third day, plasma glucose and free fatty acid concentrations, carbohydrate and lipid oxidation, and energy expenditure were identical with beta-glucan and cellulose. Plasma insulin concentrations were, however, 26% lower with beta-glucan during the last 2 h of the 9 h meal ingestion. Glucose rate of appearance at steady state was 12% lower with beta-glucan. This corresponded to a 21% reduction in the systemic appearance rate of exogenous carbohydrate with beta-glucan, while endogenous glucose production was similar with both diets. De novo lipogenesis was similar with and without beta-glucan. CONCLUSION: Administration of frequent meals with or without beta-glucan results in similar carbohydrate and lipid metabolism. This suggests that the lowered postprandial glucose concentrations which are observed after ingestion of a single meal containing beta-glucan are essentially due to a delayed and somewhat reduced carbohydrate absorption from the gut and do not result from the effects of fermentation products in the colon.
Mots-clé
Blood Glucose, Colon, Fatty Acids, Nonesterified, Fermentation, Glucans, Glucose, Humans, Insulin, Intestinal Absorption, Lipids, Male, Oxidation-Reduction, Postprandial Period
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
08/05/2019 21:59
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