Expression of Helicobacter pylori virulence factors and associated expression profiles of inflammatory genes in the human gastric mucosa

Détails

ID Serval
serval:BIB_90B23DD9C33C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expression of Helicobacter pylori virulence factors and associated expression profiles of inflammatory genes in the human gastric mucosa
Périodique
Infection and Immunity
Auteur(s)
Wen  S., Velin  D., Felley  C. P., Du  L., Michetti  P., Pan-Hammarstrom  Q.
ISSN
0019-9567 (Print)
Statut éditorial
Publié
Date de publication
11/2007
Volume
75
Numéro
11
Pages
5118-26
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Helicobacter pylori virulence factors have been suggested to be important in determining the outcome of infection. The H. pylori adhesion protein BabA2 is thought to play a crucial role in bacterial colonization and in induction of severe gastric inflammation, particularly in combination with expression of CagA and VacA. However, the influence of these virulence factors on the pathogenesis of H. pylori infection is still poorly understood. To address this question, the inflammatory gene expression profiles for two groups of patients infected with triple-negative strains (lacking expression of cagA, babA2, and vacAs1 but expressing vacAs2) and triple-positive strains (expressing cagA, vacAs1, and babA2 but lacking expression of vacAs2) were investigated. The gene expression patterns in the antrum gastric mucosa from patients infected with different H. pylori strains were very similar, and no differentially expressed genes could be identified by pairwise comparisons. Our data thus suggest that there is a lack of correlation between the host inflammatory responses in the gastric mucosa and expression of the babA2, cagA, and vacAs1 genes.
Pubmed
Web of science
Création de la notice
25/01/2008 16:58
Dernière modification de la notice
03/03/2018 19:26
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