Comparison of popliteal lymph node responses in various strains of rats.

Détails

ID Serval
serval:BIB_90A7701BE843
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of popliteal lymph node responses in various strains of rats.
Périodique
Human and Experimental Toxicology
Auteur(s)
Patriarca C., Verdier F., Brouland J.P., Vial T., Descotes J.
ISSN
0960-3271 (Print)
ISSN-L
0960-3271
Statut éditorial
Publié
Date de publication
1994
Peer-reviewed
Oui
Volume
13
Numéro
7
Pages
455-460
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Outbred (namely Wistar and Sprague-Dawley) and inbred (Wistar-Furth, Lewis, Fisher 344 and Brown-Norway) strains of rats were screened for their responses to reference compounds in the popliteal lymph node (PLN) assay. Streptozotocin and diphenylhydantoin gave positive responses as evidenced by increased weight and cellularity indices in all strains used whereas procainamide, isoniazid and barbital consistently gave negative responses. Although these findings overall are in agreement with previous investigations involving these compounds, the lack of marked interstrain differences in PLN responses argues against a strong immunogenetically controlled mechanism as could be assumed in presumably auto-immune reactions. The question is raised whether drug-induced side-effects predicted by the PLN assay are basically non-autoimmune as suggested by clinical and immunological findings in man.
Mots-clé
Animals, Barbital/toxicity, Female, Hindlimb, Isoniazid/toxicity, Lymph Nodes/drug effects, Male, Phenytoin/toxicity, Procainamide/toxicity, Rats, Rats, Inbred Strains, Rats, Sprague-Dawley, Rats, Wistar, Species Specificity, Streptozocin/toxicity
Pubmed
Création de la notice
13/10/2015 9:50
Dernière modification de la notice
03/03/2018 19:26
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