Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_90713ED33BE8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.
Périodique
Frontiers in Cellular Neuroscience
Auteur(s)
Samara C., Poirot O., Domènech-Estévez E., Chrast R.
ISSN
1662-5102 (Electronic)
ISSN-L
1662-5102
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
7
Pages
228
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
The integrity and function of neurons depend on their continuous interactions with glial cells. In the peripheral nervous system glial functions are exerted by Schwann cells (SCs). SCs sense synaptic and extrasynaptic manifestations of action potential propagation and adapt their physiology to support neuronal activity. We review here existing literature data on extrasynaptic bidirectional axon-SC communication, focusing particularly on neuronal activity implications. To shed light on underlying mechanisms, we conduct a thorough analysis of microarray data from SC-rich mouse sciatic nerve at different developmental stages and in neuropathic models. We identify molecules that are potentially involved in SC detection of neuronal activity signals inducing subsequent glial responses. We further suggest that alterations in the activity-dependent axon-SC crosstalk impact on peripheral neuropathies. Together with previously reported data, these observations open new perspectives for deciphering glial mechanisms of neuronal function support.
Pubmed
Web of science
Création de la notice
09/01/2014 18:55
Dernière modification de la notice
03/03/2018 19:25
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