Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.

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Serval ID
serval:BIB_90713ED33BE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neuronal activity in the hub of extrasynaptic Schwann cell-axon interactions.
Journal
Frontiers in Cellular Neuroscience
Author(s)
Samara C., Poirot O., Domènech-Estévez E., Chrast R.
ISSN
1662-5102 (Electronic)
ISSN-L
1662-5102
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
7
Pages
228
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
The integrity and function of neurons depend on their continuous interactions with glial cells. In the peripheral nervous system glial functions are exerted by Schwann cells (SCs). SCs sense synaptic and extrasynaptic manifestations of action potential propagation and adapt their physiology to support neuronal activity. We review here existing literature data on extrasynaptic bidirectional axon-SC communication, focusing particularly on neuronal activity implications. To shed light on underlying mechanisms, we conduct a thorough analysis of microarray data from SC-rich mouse sciatic nerve at different developmental stages and in neuropathic models. We identify molecules that are potentially involved in SC detection of neuronal activity signals inducing subsequent glial responses. We further suggest that alterations in the activity-dependent axon-SC crosstalk impact on peripheral neuropathies. Together with previously reported data, these observations open new perspectives for deciphering glial mechanisms of neuronal function support.
Pubmed
Web of science
Open Access
Yes
Create date
09/01/2014 17:55
Last modification date
20/08/2019 14:53
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