Article: article from journal or magazin.
MALDI-TOF MS-based drug susceptibility testing of pathogens: The example of Candida albicans and fluconazole.
MALDI-TOF MS can be used for the identification of microorganism species. We have extended its application to a novel assay of Candida albicans susceptibility to fluconazole, based on monitoring modifications of the proteome of yeast cells grown in the presence of varying drug concentrations. The method was accurate, and reliable, and showed full agreement with the Clinical Laboratory Standards Institute's reference method. This proof-of-concept demonstration highlights the potential for this approach to test other pathogens.
Algorithm, Candida albicans, MALDI-TOF MS, Microbiology, Proteome profiling, Target for drugs, Mass-Spectrometry, Interpretive Breakpoints, European Committee, National Committee, Clsi M27-A2, Identification, Itraconazole, Infections, Spp.
Web of science
Last modification date